While cutaneous melanoma patients have response rate of 58% and 44% to combination anti-PD1 and anti-CTLA4 or anti-PD1 monotherapy, respectively, MM patients have response rates of 37-43% and 30% to combination anti-PD1 and anti-CTLA4 and anti-PD1 monotherapy, respectively (21). This evidence concerns the gene CTLA4 and cutaneous melanoma.