According to the colon cancer Cox regression test (Table 2) and Kaplan–Meier (K-M) curves of key genetic risk factors (Figure 6), the five most significant genes selected were: ELAV-like RNA-binding protein 1 (ELAVL1), GPX2, EPAS1, SLC7A5, and high mobility group box 1 (HMGB1). The gene discussed is HMGB1; the disease is colonic neoplasm.