DECR1 and posterior cortical atrophy: What’s more, DECR1, encoding the rate-limiting enzyme for oxidation of polyunsaturated fatty acids (PUFAs), caused cellular accumulation of PUFAs, enhanced mitochondrial oxidative stress and lipid peroxidation, and induced ferroptosis. DECR1 knockdown selectively inhibited β-oxidation of PUFAs, inhibited proliferation and migration of PCa cells and the overexpression of DECR1 is associated with shorter relapse-free survival (30).