We used LASSO Cox regression analysis to demonstrate that eight genes had the highest predictive value of OS for HCC, and screened out eight genes that affect the OS prognosis of HCC patients based on the value of λ (Figures 1A, B), using the following formula to establish a prognostic signature related to cuproptosis: Risk score = (−0.04 × OGDHL+0.23 × DLAT+0.11 × CDKN2A+0.05 × GLS+0.06 × IDH3B+0.02 × IDH3G+0.01 × IDH1+0.15 × Lipt1). The gene discussed is IDH1; the disease is hepatocellular carcinoma.