We used LASSO Cox regression analysis to demonstrate that eight genes had the highest predictive value of OS for HCC, and screened out eight genes that affect the OS prognosis of HCC patients based on the value of λ (Figures 1A, B), using the following formula to establish a prognostic signature related to cuproptosis: Risk score = (−0.04 × OGDHL+0.23 × DLAT+0.11 × CDKN2A+0.05 × GLS+0.06 × IDH3B+0.02 × IDH3G+0.01 × IDH1+0.15 × Lipt1). This evidence concerns the gene CDKN2A and hepatocellular carcinoma.