Because Nrf2 is critical for immunosuppressive microenvironment formation in pancreatic cancer liver metastases via shaping the immunosuppressive phenotypes of P2RX1-negative neutrophil, future therapy, such as inhibiting the specific gene to reduce the particular phenotype of neutrophil subpopulation, may help treat pancreatic cancer. This evidence concerns the gene P2RX1 and pancreatic neoplasm.