Indeed, leonurine can inhibit PDZ-binding motif (TAZ) expression to regulate Treg/Th17 balance to alleviate rheumatoid arthritis (Du et al., 2020), it can inhibit PI3K/Akt/NF-κB signaling pathway to improve osteoarthritis (Yin and Lei, 2018), and improved renal fibrosis by inhibiting TGF-β and NF-κB signaling pathways (Cheng et al., 2015). This evidence concerns the gene NFKB1 and rheumatoid arthritis.