Moreover, six of the 16 proteins (i.e., ANXA11, FUS, HNRNPA2B1, HNRNPA1, TARDBP, and VAPB) have common genetic mutations in ALS, suggesting that these mutations may affect arginine methylation (Kabashi et al., 2008; Kim et al., 2013; Picchiarelli et al., 2019; Cadoni et al., 2020; Nahm et al., 2020). Here, TARDBP is linked to amyotrophic lateral sclerosis.