IRS1 and cancer: The most significant signal, which passed genome-wise significance (rs5839171, Pcorrected = 1.98 × 10−8, Pperm = 3.30 × 10−8), is downstream of the Insulin receptor substrate 1 gene (IRS1) and miR-5702, a microRNA involved in cellular proliferation and cancer risk (Li K. et al., 2019).