First, a recent large-scale (n > 208,000) SLE GWAS meta-analysis on East-Asian populations identified rs956237 (GWAS lead variant; intron of LEF1, Lymphoid enhancer-binding factor 1—a leukocyte transcription factor) at 4q25 as a novel susceptibility locus (Yin et al., 2020; p < 4.0 × 10−11). Here, LEF1 is linked to systemic lupus erythematosus.