The single-cell expression dataset (Lee et al., 2020) of colorectal cancer samples demonstrated that ALVRL1 was centrally distributed in endothelial tip cells and stromal cells, whereas HAUS6 did not show central distribution, which also indicates that m6A target mRNAs affected the tumor microenvironment, thereby influencing the prognosis of CRC. The gene discussed is HAUS6; the disease is colorectal carcinoma.