Finally, to confirm the underlying tumor microenvironment affected by ALVRL1 and HAUS6, the transcriptomes of single cells from CRC samples were downloaded from Single-Cell Expression Altas (https://www.ebi.ac.uk/gxa/sc/experiments/E-MTAB-8410/results/tsne), and the results indicated that ALVRL1 was centrally distributed in endothelial tip cells and stromal cells, whereas HAUS6 did not show central distribution (Figures 6F,G,H). The gene discussed is HAUS6; the disease is neoplasm.