CIBERSORT results also showed that B cell naïve, T cells CD4 memory resting, T cells CD4 memory activated, T cells gamma–delta, eosinophils, neutrophils, and dendritic cells activated elevated significantly in the low-risk group (lower m6A score group), which indicates a potential mechanism by which the m6A signature protects against CRC progression is by positively regulating immune cell infiltration. The gene discussed is CD4; the disease is colorectal carcinoma.