In the current study, we analyzed and compared the expression of 27 key m6A RNA methylation regulators in CRC tissues with recurrence and no recurrence, and we observed differential expression levels of m6A regulators (RBM15, FTO, YTHDF2, YTHDC1, EIF3A, ELAVL1, and G3BP2) both in the recurrence tissues and in the high-stage tissues, indicating their potential functions as tumor motivators in CRC tumorigenesis and recurrence. This evidence concerns the gene G3BP2 and neoplasm.