Subsequently, the multivariable Cox regression was adopted to determine the final prognostic factors by using 37 significant genes from the univariable Cox regression (p < 0.01) (Figure 6A), and six genes were recognized linked to CRC patient prognosis, namely, TOP2A, LRRC58, HAUS6, SMC4, ACVRL1, and KPNB1. The gene discussed is SMC4; the disease is colorectal carcinoma.