Therefore, we speculated that NR3C1, YY1, FOXC1, CREB1, STAT1, TFAP2C, ESR1, and PRRX2 might affected HF progression by regulating TLR4, STAT3, KRAS, and IL10 and the correlation analysis of 4 hub genes and their potential TFs was shown in Figure 4C. This evidence concerns the gene PRRX2 and hydrops fetalis.