Furthermore, ablation of Cx43 in brain gray matter astroglia reduces the severity of EAE, an animal model of MS, by promoting an anti-inflammatory phenotype in astroglia and suppressing pro-inflammatory activation of spinal microglia partly through decreased cerebrospinal fluid pro-inflammatory cytokine/chemokine levels (Une et al., 2021). The gene discussed is GJA1; the disease is myeloid sarcoma.