FMO5 and hypertensive disorder: Experimental studies revealed that hypertension leads to activation of abnormal signaling of angiotensin II (vasoactive peptide), regulate remodeling of blood vessels in response to blood-pressure dysregulation that finally promotes pro-inflammatory effects through activation of leukocytes, cell adhesion molecules, and inflammatory cytokines as well as the stimulation of NADPH oxidase, which has emerged as an important source in vascular oxidative stress and reactive oxygen species [194,198].