APP and Alzheimer disease: Evidence in support of a link between preeclampsia and pathological brain aging is strengthened by findings such as the presence of toxic protein misfolding in both AD and preeclampsia, as well as, the presence of amyloid precursor protein and increased proinflammatory cytokines in cases of preeclampsia and AD (Buhimschi et al., 2014; Minciullo et al., 2016).