Certain pre-pregnancy specific phenotypes are predictive of preeclampsia including increased android body fat, increased supine pulse, increased supine blood pressure, higher cardiac output, increased beta adrenergic responsiveness, increased popliteal pulse wave velocity, reduced renal resistance, increased C-reactive protein (CRP), elevated soluble alpha amyloid precursor protein α (sAPPα), and an exaggerated response to volume loading compared to women who did not develop preterm preeclampsia (Bernstein et al., 2017). The gene discussed is CRP; the disease is preeclampsia.