BACE1 and preeclampsia: Amyloid precursor protein-processing enzymes α-secretase ADAM10, the β-secretases BACE1 and BACE2, and the γ-secretase presenilin-1 found in the placenta have all been found to be up-regulated in cases of preeclampsia (Buhimschi et al., 2014); as β-amyloid aggregates, their presence establishes yet another link between preeclampsia and AD.