It was found that after reversing the expression of LOXL3, the migration and invasion of YTHDF3‐downregulation A375, SK‐MEL‐28 and A2058 melanoma cells were recovered to some extent, which were identified by transwell assay (Figure 8G–I) and wound healing experiment (Figure 8J–L). This evidence concerns the gene LOXL3 and melanoma.