PDE10A and ovarian carcinoma: Pf-2545920, a highly selective and potent PDE10A inhibitor previously investigated in clinical trials for treatment of CNS disorders [37], inhibited growth of normal ovarian surface epithelial cells and various ovarian cancer cell lines with IC50 values ranging from 7.6 μM to 28.6 μM (Fig. 3B left panel, Table S26).