Western-blot using a knockout validated PDE10A monoclonal antibody revealed that PDE10A protein expression was on average 28-fold upregulated in 4 out of 14 ovarian cancer cell lines (OVCAR8, SKOV3, TOV21G, and HeyA8), as compared to low or almost undetectable PDE10A protein in the remainder ovarian cancer cell lines and normal ovarian surface epithelial cells (Figs. 1B and S3A-B). The gene discussed is PDE10A; the disease is ovarian carcinoma.