Likewise, PDE10A was overexpressed in 4 ovarian cancer cell lines (OVCAR8, SKOV3, TOV21G, and HeyA8) in comparison to normal primary or immortalized ovarian surface epithelial cells, but most of the remainder 10 ovarian cancer cell lines showed very low levels of PDE10A protein expression as detected by western-blotting. The gene discussed is PDE10A; the disease is ovarian cancer.