Clinical specimens obtained from our institutional biobank replicated this finding, showing two times higher PDE10A mRNA levels in normal ovary tissue as compared to ovarian tumors, and downregulation of PDE10A in tumors of 9 out 14 patients with matched normal ovary and ovary tumors (Figs. 1D and S3D). The gene discussed is PDE10A; the disease is ovarian neoplasm.