Importantly, we found an extensive overlap between the transcriptional profile of PDE10A knockout ovarian cancer cells and that of patient provided ovarian tumors expressing high PDE10A levels, which not only revealed several key genes and pathways directly impacted by PDE10A-mediated signaling in vitro but also those of importance in the patient-tumor microenvironment. The gene discussed is PDE10A; the disease is ovarian carcinoma.