Pf-2545920, a highly selective and potent PDE10A inhibitor previously investigated in clinical trials for treatment of CNS disorders [37], inhibited growth of normal ovarian surface epithelial cells and various ovarian cancer cell lines with IC50 values ranging from 7.6 μM to 28.6 μM (Fig. 3B left panel, Table S26). Here, PDE10A is linked to ovarian cancer.