Contrary to the traditional upregulation of oncogenes in tumors when compared to normal tissue, we found that PDE10A mRNA expression is significantly decreased in ovarian tumors in comparison to normal ovaries, an observation based on qPCR data obtained with clinical specimens from our institutional cohort of ovarian cancer patients and confirmed with RNAseq data analysis of publicly available databases (TCGA and GTex). This evidence concerns the gene PDE10A and ovarian cancer.