To determine if PDE10A inhibition and activation of cGMP/PKG signaling in ovarian cancer cells can decrease β-catenin oncogenic signaling, we measured nuclear translocation of β-catenin, which subsequently binds to TCF/LEF transcription factors to induce transcription of target genes that promote growth and proliferation [42, 43]. This evidence concerns the gene HNF4A and ovarian carcinoma.