Also the TGFβ-driven expression of the leucine-rich-repeat-containing protein 15 (LRRC15) in CAFs, characterizes a pro-tumorigenic CAF subpopulation, as the depletion of LRRC15+ CAFs in PDAC models slowed tumor growth and restored CD8+ T cell functions, increasing response to immunotherapy [31]. This evidence concerns the gene CD8A and neoplasm.