In a screening of tumor cell lines derived from breast, kidney, liver, and tongue carcinomas, HGF conferred resistance to EGFR inhibitors by inducing the stabilization/upregulation of multiple EGFR binding partners such as Axl, EphA2, CUB domain-containing protein1 (CDCP1), JAK1 and integrin Beta-4 [64]. This evidence concerns the gene EGFR and neoplasm.