In pancreatic ductal adenocarcinoma (PDAC), Öhlund et al. have identified two spatially separated, reversible, and mutually exclusive subtypes of CAFs: myCAFs (myofibroblastic CAFs), closely bound to cancer cells and characterized by high αSMA expression, and iCAFs (inflammatory CAFs), located more distantly from neoplastic cells, which are characterized by significantly lower αSMA levels and elevate expression of cytokines with known roles in cancer progression, such as IL-6 and IL-1 [20]. This evidence concerns the gene ACTA1 and pancreatic ductal adenocarcinoma.