CXCL13 and Familial prostate cancer: CAF-produced cytokines could also indirectly mediate resistance; for example, CAF-derived CXCL13 promotes the recruitment of B lymphocytes into androgen-deprived prostate tumors; these prostate-cancer infiltrating lymphocytes produce other cytokines, such as lymphotoxin, promoting survival and proliferation of castration-resistant prostate cancer initiating cells, ultimately resulting in hormone resistance [80].