These differences were maintained when the samples were separated by APOE genotype (ε3/ε3 control: ratio 36 kDa/34 kDa = 1.61 vs ε3/ε3 AD: ratio 36 kDa/34 kDa = 1.46, p = 0.01; ε3/ε4 control: ratio 36 kDa/34 kDa = 1.67 vs ε3/ε4 AD: ratio = 1.38, p = 0.001; Fig. 4G). The gene discussed is APOE; the disease is Alzheimer disease.