Within the AD group, we also observed significant differences between the genotypes, as the 36-kDa/34-kDa ratio was significantly lower in APOE ε3/ε3 (p < 0.0001) and ε3/ε4 (p < 0.0001) samples when compared with ε4/ε4 AD samples (ratio 36 kDa/34 kDa = 1.64). The gene discussed is APOE; the disease is Alzheimer disease.