When a specific antibody for apoE4 was used, NBP1-49529, the 100-kDa immunoreactivity was also detected in samples from APOE ε3/ε4 AD subjects under both reducing and non-reducing conditions, while no immunoreactivity was detected in APOE ε3/ε4 control samples under non-reducing conditions (Fig. 3B). The gene discussed is APOE; the disease is Alzheimer disease.