Elevated low-density lipoprotein cholesterol (LDL-C) and other cholesterol-rich apolipoprotein B (apo B)-containing lipoproteins are key risk factors for ASCVD, and risk reduction is directly and positively correlated with the achieved absolute LDL-C reduction via lipid-lowering therapies [1, 3]. The gene discussed is APOB; the disease is atherosclerosis.