The arsenic-induced pyroptosis in NASH involved autophagy, CTSB, and the NLRP3 inflammasome cascade, and that taurine alleviated As2O3-induced liver inflammation by inhibiting the autophagic-CTSB-NLRP3 inflammasomal pathway rather than decreasing lipid accumulation [41]. This evidence concerns the gene NLRP3 and metabolic dysfunction-associated steatohepatitis.