To date, six different gene mutations have been reported in HAE nC1-INH: Factor XII (F12), plasminogen (PLG), angiopoietin 1 (ANGPT1), kininogen 1 (KNG1), myoferlin (MYOF), and heparan sulfate-glucosamine 3-O-sulfotransferase 6 (HS3ST6) [3]. The gene discussed is PLG; the disease is hereditary angioedema.