The AUC for the artificial neural network model (Fig. 2B-D) was 0.903 (95% C.I. = 0.836–0.949, 0.858 for BRCA1 and 0.855 for BRCA2), while the AUC for nomogram predicting the risk of BRCA1/2 germline deleterious mutation in Chinese bilateral breast cancer patients was 0.828 (95% C.I. = 0.750–0.890, Fig. 3). This evidence concerns the gene BRCA1 and breast cancer.