Likewise, in the lung metastatic niche, high-metastatic hepatocellular carcinoma cells typically exhibited great ability to convert normal fibroblasts into CAFs, which was mediated by exosomal miR-1247-3p derived from HCC cells that activated CAFs via the B4GALT3-β1-integrin-NF-κB axis. The gene discussed is B4GALT3; the disease is hepatocellular carcinoma.