Meanwhile, Bose et al. firstly confirmed that tumor-derived pericytes had a negative influence on the proliferation and activation of CD4+ T cell as well as resulted in CD4+ T cell dysfunction even anergy in response to antigen in an IL-6-dependent manner, which possibly hampered effective antitumor immune responses and shielded tumor cells from the host immune attack [317]. Here, IL6 is linked to neoplasm.