For example, a patient with tumor size < 2 cm, well to moderately differentiated histologic grade, invasions of tumor cells in subcutaneous fat, no history of organ transplantation, low expression of Axin2, and high expression of p53 would have a total score of 170, which would correspond to a probability of recurrence of 18.0%, 53.5%, and 78.7% in 1, 3, and 5 years, respectively. This evidence concerns the gene TP53 and neoplasm.