Kaplan–Meier analysis showed that the immunoreactivity of p53, ARID1A, Axin2, pTyr421-CTTN, pTyr466-CTTN, MAGEA12, p16, and Snail were significantly related to the recurrence-free survival of cSCC patients (Supplementary Fig. 2). Here, MAGEA12 is linked to skin squamous cell carcinoma.