But no significant association of the GRS with other obesity-related metabolic variables such as SBP, DBP, FBS, TG, TC, LDL-C, VLDL-C, HDL, HOMA-IR, insulin, MCP-1, PAI-1, and Galectin3 was seen in the crude model (Table 3) (Fig. 2). Here, SERPINE1 is linked to obesity due to melanocortin 4 receptor deficiency.