Therefore, the present study has been undertaken to compute the GRS through traits associated with obesity-related genetic markers, namely, MC4R (rs17782313), CAV-1(rs3807992), and Cry-1 (rs2287161), to improve the identification of overweight and obese women at a higher risk of developing cardio-metabolic risk factors. The gene discussed is MC4R; the disease is obesity due to melanocortin 4 receptor deficiency.