TIRAP and rheumatoid arthritis: Given its high hydroxymethylation (logFC = 1.07, P ≤ .05, FPKM ≥ 0.05) and upregulated transcriptional expression (logFC = 0.95, P ≤ .05, FPKM ≥ 0.05) of TIRAP, TIRAP may be the most important epigenetic biomarker gene for targeted identification of RA heat syndrome.