We compiled a list of 99 VUS in the last 260 aa of MLL1-3 within or near the catalytic SET domain, (29 in MLL1, 44 in MLL2, 26 in MLL3, Supplementary File 1) from the Catalog of Somatic Mutations In Cancer (COSMIC) database27 and from exome sequencing of 308 tumors of various origins at the Mayo Clinic28. Here, KMT2C is linked to cancer.