In 10 patient-derived xenograft (PDX) models of castration-resistant prostate cancer (LuCaP PDX series)22, we detected B7-H3 expression in each PDX tumor pair and found a positive trend between mRNA and protein expression (n = 10, r = 0.52, p = 0.06) (Supplementary Figs. 1b–c and 4). Here, CD276 is linked to Familial prostate cancer.