A recent study involving a cohort containing 412 Chinese patients with invasive breast cancer revealed that Chinese patients had a higher PIK3CA alteration frequency (45.6% vs. 34.7%; P < 0.001) compared to Caucasians in The Cancer Genome Atlas (TCGA) (N = 453), indicating that an alteration in PIK3CA deserves greater attention among Chinese patients [43]. Here, PIK3CA is linked to invasive breast carcinoma.