Although few previous reports have examined the association between PMVK and cancer, PMVK is reported to be differentially related to the multidrug response of ER-positive and ER-negative cells, with expression positively correlated with the drug response in ER-positive cells and negatively correlated with the drug response in ER-negative cells in breast cancer48, suggesting that PMVK might serve as a prognostic marker for breast cancer. The gene discussed is PMVK; the disease is cancer.