PDCD1 and neoplasm: In addition, nociceptor-ablated mice showed an increase in the total number and relative frequency of cytotoxic (IFNγ+, TNF+or IL-2+) tumour-infiltrating CD8+ T cells, but a reduced proportion of PD-1+LAG3+TIM3+ CD8+ T cells (Fig. 3d,e and Extended Data Fig. 6a,b).