Given that nociceptor-released CGRP is increased when cultured with B16F10 cells (Fig. 1c) or exposed to SLPI (Fig. 2f), and that tumour-infiltrating nociceptor neurons overexpress Calca (Fig. 1d,e), we next sought to test whether the intratumoral levels of CGRP correlate with CD8+ T cell exhaustion. This evidence concerns the gene CALCA and neoplasm.