We found that vehicle-exposed B16F10-mCherry-OVA-bearing mice succumbed at a 2.7-fold higher rate (P ≤ 0.02) than QX-314-exposed mice (Extended Data Fig. 8j; measured until day 19). As observed 17 days after tumour inoculation, QX-314-mediated silencing of sensory neurons (0.3%; daily i.d., surrounding the tumour) reduced melanoma growth and limited the exhaustion of intratumoral CD8+ T cells (Extended Data Fig. 8k–n). Here, CD8A is linked to melanoma.