Injection of recombinant human IL-6 into young female NZB/W F1 mice (6 months of age) accelerated membranoproliferative glomerulonephritis by upregulating the expressions of mesangial MHC class II and glomerular intercellular adhesion molecule-1 (ICAM-1)41. The gene discussed is ICAM1; the disease is membranoproliferative glomerulonephritis.