Previous studies have shown that the serum levels of IL-6, MCP-1 (CCL2), and TNF-α are elevated in SLE patients; serum levels of MCP-1 were also significantly higher in SLE patients than in healthy controls, and serum levels of MCP-1 were positively correlated with SLEDAI38. The gene discussed is TNF; the disease is systemic lupus erythematosus.