The median ratios of C5AR1, CLEC4A and NLRP3 expression in early-stage NSCLC patients compared to healthy volunteers were 0.014 [range 0–0.37] vs. 0.01 [range 0–0.07, p = 0.13], 0.03 [range 0–0.87] vs. 0.02 [range 0–0.13, p = 0.10] and 0.19 [range 0–0.6] vs. 0.09 [range 0.02–0.31, p < 0.0001], respectively (Fig. 1a, Table 2). This evidence concerns the gene NLRP3 and non-small cell lung carcinoma.