The median fluorescence intensity (MFI) of CD3+C5AR1+, CD3+CLEC4A+ and CD3+NLRP3+ expressions in early-stage NSCLC patients compared to healthy volunteers were 185 [range 64.2–480] vs. 107.5 [range 27–229, p < 0.0001], 91.2 [range 42.4–2355] vs. 71.2 [range 46.2–103, p = 0.0005] and 1585 [range 478–5224] vs. 758.5 [range 318–1976, p < 0.0001], respectively (Fig. 1b, Table 2). Here, NLRP3 is linked to non-small cell lung carcinoma.