Median adjusted fluorescence intensity of CD3+C5AR1+, CD3+CLEC4A+ and CD3+NLRP3+ cells in the early-stage NSCLC compared to healthy volunteers were 2.80 [range 0.63–1758.44] vs. 1.01 [range 0.03–15.21, p = 0.007], 2.49 [range 0.15–2037.22] vs. 1.39 [range 0.27–12.97, p = 0.02], and 286.79 [range 0.41–3138.03] vs. 64.67 [range 11.09–517.74, p < 0.0001], respectively. Here, CLEC4A is linked to non-small cell lung carcinoma.