Several previous studies demonstrated that NLRP3 inflammasome regulates lung cancer proliferation and metastasis through a variety of mechanisms30–33 including promoting phosphorylation of Akt, ERK1/2, and CREB, enhancing Snail expression, decreasing E-cadherin expression30, and increasing inflammatory cytokine secretion such as interleukin-1 β32–34. Here, CREB1 is linked to lung cancer.