In this study, we also examined stromal AR action in Gli1-lineage cells to promote PIN and tumor progression by injecting TM to 2-month-old Hi-Myc:ArL/Y:Gli1CreER/+ and Hi-Myc:Gli1CreER/+ mice and analyzed them at 6-months of age (Supplementary Fig. 1f). This evidence concerns the gene MYC and neoplasm.