AR and prostate adenocarcinoma: Given HGPIN lesions and prostatic adenocarcinoma lesions developed in 2- and 6-month-old Hi-Myc:Gli1CreER/+ mice, we performed single-cell RNA sequencing (scRNA-seq) using prostate tissues of 3-month-old HiMyc and HiMyc-ARKO mice to assess the molecular mechanisms for stromal AR signaling in early prostate epithelial tumorigenesis.