Increased IGFBP3 expression was also identified in prostatic stromal cells of HiMyc-ARKO mice when the Ar was deleted at 2 months of age (Supplementary Fig. 4g1–i3), corresponding to the impaired PIN and prostate tumor development in these mice (Supplementary Fig. 1f–j). The gene discussed is IGFBP3; the disease is prostate neoplasm.