IGF1 and prostate cancer: GSEA based on the above DEGs identified the enrichment in upregulated pathways that promote prostate cancer (p = 0.006) and androgen signaling activation (p = 0.016), and downregulated pathways related to cell hypoxia (p = 0.019), negative responses to insulin and IGF1 (p = 0.015), and P53-mediated signaling (p = 0.025) in the mGFP+ Ar+ FB1 of HiMyc samples (Fig. 5n).