TM6SF2 and metabolic dysfunction-associated steatotic liver disease: In addition to PNPLA3-rs738409, many other genetic variants have been found to be associated with increased risk of NAFLD, including transmembrane 6 superfamily member 2 (TM6SF2)-rs58542926 and 17β-hydroxysteroid dehydrogenase-13 (HSD17B13)-rs72613567.