We further unraveled that hepatic 17β-HSD13 expression is upregulated by LXRα in an SREBP1c-dependent manner18 and overexpression of 17β-HSD13 leads to excessive lipid accumulation in association with increased transcriptional activity of SREBP1c7, suggesting a vicious cycle between 17β-HSD13 and SREBP1c in NAFLD. This evidence concerns the gene NR1H3 and metabolic dysfunction-associated steatotic liver disease.