Four lncRNAs appeared in more than one type of cancer and were differentially regulated, including downregulation of LINC00473 in ESCC radiosensitivity and upregulation in HNSCC and NSCLC radioresistance, downregulation of NEAT1 in NPC radiosensitivity and upregulation in cervical cancer radioresistance, downregulation of LINC00958 in colorectal cancer radiosensitivity and upregulation in cervical cancer radioresistance, downregulation of PVT1 in NPC and NSCLC radiosensitivity and upregulation in NPC radioresistance. The gene discussed is NEAT1; the disease is esophageal squamous cell carcinoma.