cBF neuronal lesioning in a range of mouse AD models exacerbates many features of AD, including promoting cognitive impairment, and increasing Aβ accumulation, plaque load, and inflammation (as observed herein), as well as causing tau hyperphosphorylation, hippocampal degeneration, and reduced neurotrophin expression40–42,71,72. Here, BDNF is linked to Cognitive impairment.