APP and Alzheimer disease: Similarly, in our study, induced SDB in older APP/PS mice (already predisposed to overproduce Aβ peptides) resulted in more severe cognitive impairment than that observed in their age-matched littermates, and exacerbated many of the pathological features of AD, including induction of cBF degeneration, Aβ accumulation within the cortex and hippocampus, and increased inflammation represented by astro- and gliogenesis.