Similarly, mice exposed to intermittent hypoxia during sleep (alternating 60 s epochs of 21 and 0% O2 for 8 h) developed hippocampal synaptic changes and cognitive impairment in the Barnes maze spatial memory test46, a memory test which are sensitive to cBF function59; these phenotypes were similarly prevented by heterozygous knockout of HIF1α46. This evidence concerns the gene CEBPZ and Cognitive impairment.