Other pathogenic mutations that were detected in the non-MPN patients included abnormalities in several clonal hematopoiesis of indeterminate potential (CHIP) genes (e.g., DNMT3A, TET2 and SF3B1); however, all exhibited variant allele frequencies greater than 20%, and some even higher in the 50% and 60% range. The gene discussed is DNMT3A; the disease is myeloproliferative disorder.