Recently it has been shown that the HUSH complex, particularly MPP8, which is downregulated in many cancer types and whose depletion caused overexpression of long interspersed element-1 (LINE-1s) and Long Terminal Repeats, controls type I Interferon signaling involving a mechanism with dsRNA sensing by MDA5 and RIG-I40. The gene discussed is MPHOSPH8; the disease is cancer.