CD4 and cancer: We found that cancer cells were easier to grow in LXN-deficient mice, and more M2 macrophages (F4/80+CD11b+CD16/32−CD206+) and fewer T cells (CD3+CD4+ and CD3+CD8+) were observed in the tumor tissues of LXN−/− mice (Fig. 2), suggesting it is universal that the changes of immune environment caused by LXN deficiency are conducive to tumor growth.