Upon analyzing T cell infiltration in tumor tissue, we found that, as expected, WT-MØ injected into LXN−/− mice increased CD3+CD4+ and CD3+CD8+ T cells in tumor tissue, however, KO-MØ further attenuated T cells (Fig. 8F), supporting the hypothesis that LXN-deficient macrophages inhibited T cells, while WT-MØ could rescue the function of T cells in LXN−/− mice, at least in partial, in tumor microenvironment. This evidence concerns the gene CD8A and neoplasm.