Gene set enrichment analysis (GSEA) of differentially expressed genes revealed robust activation of both innate antiviral immune response and adaptive immunity, including response to type I and type II interferon, T-cell-mediated immunity, etc. in Mll3−/− or Mll4−/− tumor cells (Fig. 3c and Supplementary Fig. 3c). Here, KMT2D is linked to neoplasm.