Elevated immune cytotoxicity in MLL3- and MLL4- low tumors not only results from the higher degree of T-cell infiltration but is also contributed by the increased cytotoxicity of infiltrated CD8+ T cells as the inverse correlation between the expression of MLL3 or MLL4 with the ratio of GZMB/CD8 transcripts was observed in most TCGA tumor types (Fig. 2o), which is in line with our findings in murine melanoma. This evidence concerns the gene KMT2D and melanoma.