Though we found MLL4 depletion also decreases the levels of DNMT3A and DNMT1 in human cancer cell lines we tested, their transcriptional downregulation may not trigger derepression of GSDMD and other inflammatory caspases in other human cancer cell lines as genetic inactivation of both genes have been observed in hematological malignancy and solid tumors. Here, KMT2D is linked to cancer.