In line with this, MLL4 depletion dramatically increases the expression of genes encoding MHC I machineries and components in antigen processing and presentation pathways in both murine B16 melanoma cells and a few examined human cancer cell lines (Fig. 3e and Supplementary Fig. 3f), most of which are also transcriptionally induced in Mll3−/− B16 tumor cells as well (Supplementary Fig. 3g). This evidence concerns the gene KMT2D and melanoma.