AGO2 and neoplasm: In addition to more intratumoral CD8+ T cells, the increased immune cytotoxicity in AGO2-low tumors may also be contributed by stronger cytotoxicity of infiltrated CD8+ T cells as inverse correlations were observed for the expression of AGO2 with the ratio of GZMA/CD8A mRNA level-in diverse TCGA tumor types as well (Fig. 3s).