Bioinformatic analyses reveal that AGO2 expression is negatively correlated with the mRNA levels of CD3, CD8A, and GZMA in a variety of TCGA human tumor types (Fig. 3q, r), indicating AGO2-low tumors have a higher abundance of total and CD8+ T cells and stronger immune cytotoxic activity. The gene discussed is CD8A; the disease is neoplasm.