In contrast to the comparable tumor growth rate in immuno-deficient mice (Supplementary Fig. 2a–d), OT-I CD8+ T-cell transfer results in much slower progression and reduced tumor burden of Mll3−/− or Mll4−/− B16 cells in Rag1−/− mice as compared to the control tumors, indicating ablation of MLL3 or MLL4 promotes the anti-tumor function of adoptive CD8+ T cells (Fig. 2e, f). This evidence concerns the gene KMT2D and neoplasm.