Analyses of RNA-seq datasets in TCGA and CCLE for human tumors and cancer cell lines revealed prominent positive correlations for MLL4 expression and the mRNA levels of DNMT3A or DNMT1 (Fig. 6c and Supplementary Fig. 6c), indicating MLL4 may have a universal role in transcriptional activation of DNA methyltransferases in human cancer cells of various tissue origins. Here, DNMT1 is linked to cancer.