GZMA and neoplasm: GSDMD transcript level positively correlates with the mRNA levels of CD3, CD8A, GZMA, GZMB, PRF1, and the mRNA ratio of GZMA or GZMB to CD8A in the vast majority of TCGA tumor types (Fig. 4i–k and Supplementary Fig. 4h), indicating higher expression of GSDMD is associated with more infiltration and stronger cytotoxic activity of CD8+ T cells.