KMT2C and neoplasm: We found levels of both full-length and N-terminal fragment of GSDMD are elevated in Mll3−/− and Mll4−/− bulk tumors (Fig. 4c and Supplementary Fig. 4c, d), indicating that Mll3 and Mll4 deletion induces GSDMD expression and could transcriptionally prime tumor cells for pyroptosis.