We found expression of cytosolic dsRNAs and dsDNAs sensors is markedly increased in Mll3−/− or Mll4−/− tumor cells (Fig. 3h and Supplementary Fig. 3h) and depleting two of the dsRNAs sensors, MDA5 and RIG-I (encoded by Ddx58), partially rescues the tumor growth defects and abrogates the survival advantages of C57BL/6J mice implanted with Mll4−/− melanoma cells (Fig. 3i, j), indicating the necessity of innate dsRNAs sensing pathways in the efficient immune clearance of Mll4−/− tumors in immune-competent mice. This evidence concerns the gene KMT2C and neoplasm.