Besides the enrichment of antiviral interferon response and T-cell-mediated adaptive immunity (Fig. 3c and Supplementary Fig. 3c), GSEA analyses also revealed pronounced induction of genes involved in pyroptosis, including pyroptotic executioner Gsdmd and the inflammatory Casp1 and Casp11 in Mll3−/− and Mll4−/− melanoma cells (Fig. 4a and Supplementary Fig. 4a). This evidence concerns the gene KMT2D and melanoma.