To determine how MLL3 or MLL4 suppresses anti-tumor T-cell immunity, we performed total RNA-seq analyses of tumor cells sorted out from C57BL/6J mice inoculated with GFP-labelednon-targeting control, Mll3−/− or Mll4−/− B16 cells (Fig. 3a, b, and Supplementary Fig. 3a, b). The gene discussed is KMT2C; the disease is neoplasm.