GSDMD and neoplasm: Moreover, anti-PD-1 treatment further increases the abundance and promotes the cytotoxic potential of CD8+ T cells in tumors ectopically expressing wild-type GSDMD (Fig. 7d, e), suggesting PD-1 blockade and GSDMD can synergize with each other to potentiate anti-tumor efficiency of cytotoxic T lymphocytes.