Ectopic expression of Dnmt3a and Dnmt1 alone or in combination abolishes the increased expression of Gsdmd in Mll4−/− B16 cells (Fig. 6p), suggesting defects in DNMT3A and DNMT1 -catalyzed promoter CpG methylation are responsible for the transcriptional derepression of GSDMD-triggered pyroptosis in Mll4−/− melanomas. Here, KMT2D is linked to melanoma.