We found levels of both full-length and N-terminal fragment of GSDMD are elevated in Mll3−/− and Mll4−/− bulk tumors (Fig. 4c and Supplementary Fig. 4c, d), indicating that Mll3 and Mll4 deletion induces GSDMD expression and could transcriptionally prime tumor cells for pyroptosis. Here, KMT2D is linked to neoplasm.