MYC and neoplasm: MYC-induced reduction of TILs was also observed in B1P-MycERT2 tumors induced by intraductal injection of lentiviral MycERT2-P2A-Cre as well as in orthotopically transplanted WB1P tumor-derived organoids that were transduced with lentiviral MycERT2, where we also observed a correlation of tumor growth inhibition with immune infiltration upon MYC withdrawal (Supplementary Fig. S6C–E).