In line with this, whereas pIRF3 levels were increased upon BRCA2 depletion, pIRF3 levels were only marginally affected by MYC overexpression, supporting a more downstream mode of action than micronuclei formation and the resulting pIRF3 activation in BT-549 cells (Fig. 3H, Supplementary Fig. S5A), suggesting differences between the human TNBC cells and mouse mammary tumor organoids. Here, BRCA2 is linked to breast cancer.