DNER and cancer: Because alterations in theregulation of activities by BET proteins, especially BRD4,12 are associated with different inflammatory diseasesand cancer, several BET degraders, including dBET1,13 MZ1,14 dBET21,15,16 and ARV-77117 (Figure 3) bearing (+)-JQ118,19 as a warhead, have been developed, with the ultimate goal of findingmore effective treatments compared to small-molecule inhibitors.18−20