TNF and amyotrophic lateral sclerosis: It has been shown that T and B cells, especially LM-B, can acquire an SASP, stepping up production and secretion of proinflammatory cytokines such as IL-2, IL-6, IL-8, tumor necrosis factor and interferon-γ.14 We could therefore speculate that senescent lymphocyte may contribute to neuronal degeneration and to disease progression in ALS.