In summary, this study showed that the SNPs rs1012603 of Nogo-A were significantly correlated with CP, and the correlations were also found in spastic diplegia, GMFCS I of CP, ADL (>9) of CP, and female subgroups, indicating that Nogo-A might mainly affect mild types of CP and there might be sex-related differences, which provides novel evidence for the role of Nogo-A in CP and contributes to our understanding of the molecular mechanisms of this neurodevelopmental disorder. The gene discussed is RTN4; the disease is spastic diplegia.