RTN4 and spastic diplegia: Based on our previous research on Nogo-A [37], this study further discovered that the rs1012603 SNPs in Nogo-A were significant differences between CP with spastic diplegia, GMFCS I of CP, the ADL (>9) of CP, the female subgroups, and controls, which implied that the Nogo-A mainly affected mild CP children and there might be sex-related differences.