APOE and Alzheimer disease: Table 3 shows SNPs with the strongest 3-way dependence with AD and APOE. Note that four of these modifier SNPs have a p-value of <0.0001. Note that these SNPs modify the dependency between the APOE SNP and the AD phenotype, so these are modifier alleles. Table 4 and Figure 4 show the location and nearest genes for the strongest SNPs, and notes the literature indicating the connections to AD.