We used the common ccRCC line 786-O (Brodaczewska et al., 2016), derived from a VHL-deficient, H2 type primary ccRCC, wherein HIF-2α is stabilized due to an inactivating mutation in VHL (the E3 ubiquitin ligase that targets all HIF-α isoforms for proteasomal degradation) (Gnarra et al., 1994). The gene discussed is EPAS1; the disease is nonpapillary renal cell carcinoma.