A structure-based sequence alignment revealed that Ser284 in human AAR2 corresponds to Ser253 in yeast Aar2p (Supplementary Fig. S1; Fig. 3 ▸e), and AAR2 has been found to be phosphorylated at Ser284 in human liver cancer cells (Hornbeck et al., 2012 ▸). The gene discussed is AAR2; the disease is liver cancer.