Mutations in the prpf8 gene can lead to retinitis pigmentosa (RP; Růžičková & Staněk, 2017 ▸), a disease that causes blindness in humans, and the corresponding PRPF8/Prp8p variants cause defects in U5 snRNP assembly (Malinová et al., 2017 ▸) and splicing (Mayerle & Guthrie, 2016 ▸; Mozaffari-Jovin et al., 2013 ▸) in humans and yeast. This evidence concerns the gene PRPF8 and blindness (disorder).