NFE2L2 and chronic kidney disease: In this brief review, we present recent developments in the research on the role of the NRF2-mediated antioxidant response signaling pathway for the maintenance of muscle mass in patients with CKD, through its impact on protein degradation by UPS and other mechanisms, and present examples of potential non-pharmacological interventions using nutraceutical activators to improve redox homeostasis, aiming at preventing skeletal muscle wasting associated with PEW in patients with CKD.