TRIM63 and chronic kidney disease: This effect of EGCG could play a role as a treatment of PEW in patients with CKD, since its antioxidant action has been associated with prevention of unintentional weight loss; EGCG attenuates leukocyte infiltration into the skeletal muscle by decreasing NFkB, MuRF1 and MAFbx, thereby reducing the inflammatory activity and favoring regeneration of muscle fibers [50].