While an ongoing RCT may soon provide important insights [78], to date only a few studies have investigated whether genetic variants associated with plasma SAA concentrations are also associated with obesity, and focused on the methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism as determinant of plasma tHcy concentrations [10]. This evidence concerns the gene MTHFR and obesity due to melanocortin 4 receptor deficiency.