Finally, DYT28 is associated with KMT2B,45 encoding another methyltransferase reported to methylate H3K4.46 Phenotypically, the KDM2B related disorder shares features with HMA, eg, mild to moderate developmental delay, CHDs, and dysmorphism, but presents differently from ADCADN and DYT28. This evidence concerns the gene KMT2B and Global developmental delay.