Finally, DYT28 is associated with KMT2B,45 encoding another methyltransferase reported to methylate H3K4.46 Phenotypically, the KDM2B related disorder shares features with HMA, eg, mild to moderate developmental delay, CHDs, and dysmorphism, but presents differently from ADCADN and DYT28. Here, KMT2B is linked to autosomal dominant cerebellar ataxia, deafness and narcolepsy.