Interestingly, the KDM2B related disorder, ADCADN, HMA, and DYT28 episignatures are all characterized by hypermethylation.2,47,48 The elevated MVP scores might therefore reflect a set of loci sensitive to hypermethylation, irrespective of the underlying mechanisms. The gene discussed is KDM2B; the disease is autosomal dominant cerebellar ataxia, deafness and narcolepsy.